Sadly, most manufacturers don’t know about all the research being done into polyethylene glycol and its derivatives. How to use Polyethylene Glycol 3350 17 Gram/Dose Oral Powder. Following administration of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, up to 85% to 99% of the compound was excreted in the feces. All animals are susceptible to ethylene glycol (EG) toxicity, but it is most common in dogs and cats. Call your doctor if you are still constipated or irregular after using this medication for 7 days in a row. It is also used to empty the intestines prior to diagnostic procedures. Leib MS. Colonoscopy. Sign up for the Dogs Naturally Newsletter and get over 200 FREE Health Plans and Guides in 2020. The FDA says dogs can handle small doses. HATs The unique sensitivity of cats as a species means any plan, whether short or long. From the information that I found, it would not make sense for natural product and cosmetic manufacturers to use PEG and PEG derivatives but they do. She had just gotten spayed.  It is also not approved for breeding, nursing or lactating dogs or cats but is considered safe by many veterinarians. ©Copyright 1999 - 2020. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. It is commonly used in humans before diagnostic procedures such as colonoscopy. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. Polyethylene glycol (PEG; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. Her practice incorporates herbal medicine, complementary therapies and environmental stewardship to help dogs and people find balance and partnership with nature. Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. PEG 3350 is an over-the-counter laxative sold using th… The Food and Drug Administration (FDA) has classified propylene glycol as . Since it has a wider margin of safety as compared to its chemical cousin, ethylene glycol, it is commonly used to absorb extra water and maintain moisture in certain medicines, cosmetics, or dog and human food products. Polyethylene glycol functions as a “penetration enhancer,” which means it increases the permeability of the skin to allow the rapid absorption of substances through the skin layer. Seek medical attention if warranted.” Um, how can anyone think that rubbing PEG on any type of skin is a good idea after reading this warning? It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. Tweet. It is also used to empty the intestines prior to diagnostic procedures. In cats, the dose of Polyethylene Glycol 3350 Powder for the solution most commonly used is as a laxative is 1/8 to ¼ teaspoon every 12 hours on food. That’s why you must base the dog’s dose on their weight (rather than what the drug’s leaflet says). Constipation Resolution with Administration of Polyethylene-Glycol Solution in Cats (Abstract). Drug Metab Dispos 2007. At 8 hours after dexamethasone administration, 18 of 18 (100%) dogs with hyperadrenocorticism given the sodium phosphate preparation and 16 of 18 (89%) affected dogs given the polyethylene glycol preparation failed to have suppression of plasma cortisol concentration (less than 1.4 micrograms/dl). Many animals will voluntarily drink ethylene glycol if antifreeze is spilled or leaks onto garage floors or driveways. The IHC Group. This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug. Some pets will appear to strain which can look like constipation but is actually. There are versions of Polyethylene glycol that contain electrolytes used primarily for preparation for colonoscopy in humans including the product “Golytely®”.  Paddock Laboratories, LLC. The Cosmetic Ingredient Review board (CIR) studies chemical compounds found in cosmetics. Products include CL® Solution; CoLyte®; GoLYTELY®; NuLytely®, TriLyte®, MoviPrep®. This quality makes the chemical extremely versatile as an additive to everything from antifreeze to food. Half-life. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Polyethylene glycol 3350. Symptoms of Propylene Glycol Toxicity in Dogs. It is commonly used in humans before diagnostic procedures such as colonoscopy. Pelletier explained to iHeartDogs.com that propylene glycol is commonly used as a sweetener in dog products because “it’s cheap and readily available.” As mentioned in the TATSDR report, it’s also used as a preservative and to remove moisture in dry foods. Polyethylene Glycol 3350 Powder for the solution is available in either pre-measured 17-gram packets or bulk powder such as MiraLax®, Dulcolax Balance®, and various generic products. The PEG 400, 1000, 1540 and 4000 are cleared from the plasma at a rate identical with that of creatinine in the normal, lightly anaesthetized animals (Schaffer & Critchfield, 1947). Propylene glycol is a colorless, odorless synthetic liquid that absorbs water. Then, I came across a new wellness product she had been using that contained polyethylene glycol. In dogs, the dose of Polyethylene Glycol 3350 Powder for solution varies with the size of the dog: Small dogs – 1/8 to ¼ teaspoon every 12 hours (twice daily), Medium sized dogs – ¼ to ½ teaspoon every 12 hours (twice daily), Large dogs – ½ to ¾ teaspoon every 12 hours (twice daily). These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems.  Plumb’s Veterinary Handbook by Donald C. Plumb, 9th Edition. Polyethylene glycol 3350 belongs to the class of drugs known as osmotic laxatives. Ethylene glycol has a very narrow margin of safety – which means only a tiny amount can result in severe poisoning. Her diet was perfect, her home environment was as non-toxic as you can get. Be certain to complete the prescription unless specifically directed by your veterinarian. Anaheim, CA, USA. Caution: Some dogs don’t react well to PEG or polyethylene glycol (the primary active ingredient). 1,4. Use of methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo-controlled, randomized, blinded trials in dogs. Polyethylene glycol 3350 should produce a bowel movement within 1 to 3 days of using the medication. Here is the rub: Polyethylene glycol should not be in anything that you feed your dog or put on their skin, especially damaged skin. Aspiration is an uncommon but potentially devastating complication of polyethylene glycol administration. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse. Polyethylene glycol works by creating and environment where water is retained in the stool. Sounds healthy, right? Most intoxications are associated with ingestion of antifreeze, which is typically 95% EG. 1950). Propylene glycol is not as toxic as another common antifreeze ingredient known as ethylene glycol; however, it is still poisonous and dogs require medical treatment if ingested. No metabolism of PEG400 to ethylene glycol after oral administration to dogs and man could be demonstrated (determination of oxidizable substances in the plasma, Shaffer et al. Gently wash all affected skin areas thoroughly with soap and water. After some research, I realized there are a large number of products containing polyethylene glycol being marketed to pets and those numbers are growing. Polyethylene glycol (PEG) is a water-soluble, inactive ingredient of which only a very small amount is absorbed in the gut or gastrointestinal tract , the rest moves through the body. If you suspect your cat has symptoms of Heinz body, contact your veterinarian for testing and treatment. Textbook of Veterinary Internal Medicine, Ettinger & Felman. Proceedings: ACVIM. Propylene glycol poisoning in dogs is caused by ingesting propylene glycol. The product my client was using was for her dog’s surgical wound. “We just don’t know with specificity what those levels are,” says Becker. The renal clearance rates of a series of polyethylene glycols ranging from 400 and 6000 molecular weights have been determined in the dogs. Another issue that polyethylene glycol has is contamination. As little as half a teaspoon per pound of a dog’s body weight can result in fatality. If the above wasn’t enough, polyethylene glycol also destroys the beneficial bacteria found on your dog’s skin and inside their stomachs. Miralax is a laxative that can primarily treat constipation in dogs. Polyethylene glycol 3350, commonly known as MiraLAX® as well by many other trade names (see below), is used as a laxative to treat constipation for dogs and cats. Minneapolis, MN, USA; 2016. This is most commonly seen when pets ingest liquid, high concentration propylene glycol … Polyethylene glycol 3350 is available in various solutions that have added electrolytes primarily used in humans as preparation for colonoscopy diagnostic procedures. American Society of Hospital Pharmacists. The bigger GP issue is with cats. Administering Miralax. Propylene glycol (PG) is one of the least toxic glycols.. Cats are particularly sensitive to PG and its use is no longer allowed in cat foods. Propylene glycol is a common ingredient in antifreeze, lubricants, and products of plasticity. Ingestion of sufficient amounts can be fatal”. Yes No. PEG “400” shows that the common molecular weight of the specific PEG is four hundred. However, according to Dr. Karen Becker, an integrative wellness veterinarian, propylene glycol can be toxic to dogs at certain levels. The starting dose is 1/8 to teaspoon BID, and this dose is titrated upwards depending on desired stool consistency.  Ogbru O. We'd love your feedback! Polyethylene Glycol 3350 (MiraLAX) for Dogs and Cats – PetPlace. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. Carr, A. The oral LD 50 of PG in dogs is ~9 mL/kg. Las Vegas, NV, USA; 2008. In: 80th Annual Western Veterinary Conference Notes (WVC 2008). Carr A, Gaunt M. Constipation resolution with the administration of polyethylene-glycol solution in cats. © 2020 Dogs Naturally Magazine Inc. Anaphylactic reactions to macrogol are rarely reported. MATERIALS AND METHODS Rita Hogan CH is a canine herbalist and co-founder of Farm Dog Naturals, an herbal remedy company for the All-Natural Dog. Common names include Clearlax, Colyte, Dulcolax, Easylax, EZ2GO, Gavilax, Gavilyte, Gialax, Glycolax, Golytely, Healthylax, Laxaclear, Miralax, Moviprep, Natura-Lax, Nulytely, Pegylax, Powderlax, Purelax, Smooth lax, and Trilyte. Polyethylene Glycol 3350 (MiraLAX) for Dogs and Cats Posted by By Admin May 21, 2020 No Comments. It’s actually the brand name of a medicine also known by the generic name polyethylene glycol 3350. Different types of macrogol exist according to their molecular weight from 300 g/mol to 10,000,000 g/mol . Here is the rub: Polyethylene glycol should not be in anything that you feed your dog or put on their skin, especially damaged skin. To find a holistic or homeopathic vet near you or to find one who will do phone consultations, visit The Academy Of Veterinary Homeopathy. Polyethylene glycol 3350 may interact with other medications. Polyethylene glycol 3350 is available without a prescription but should not be administered unless under the supervision and guidance of a veterinarian. It is widely used as an additive in pharmaceuticals, cosmetics and food . If you need help, call us at 800.786.4751.-The Revival Education Team Was this helpful? Dogs rely on these bacteria for a healthy immune system and a balanced pH level. In: 2010 ACVIM Forum Proceedings. The content on this website is not meant to replace veterinary advice. PEG is manufactured for use in paints, wood treatments, detergents, cleaners and coatings. Dogs may be attracted to ethylene glycol by its sweet taste. PEG is non-toxic and has no effect on the body. If you don’t know what something is, research it and find out if it is safe for you and your dog. Scary. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Polyethylene glycol moderately non-toxic and its absorption into the physique is less than 0.5%. Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. Cisapride is often the prokinetic of choice. Share. & M. Gaunt (2010). Longer-term use can cause electrolyte imbalances including high potassium and/or low sodium or cause dehydration. Polyethylene glycol 3350 .San Clemente, CA, USA: Medicinenet.com; 2015. Please support the hard working holistic vets who make this information possible. If you’d like more on how we use your information, just check out our Privacy Policy. But though it is considered generally safe for human and animal consumption, cats have a unique sensitivity to propylene glycol … The actual molecular weight is not less than 90.0 percent and not greater than 110.0 percent of the nominal value. A white powder for reconstitution. Polyethylene glycol 3350 is used to stimulate bowel movements in animals with. Finding out that manufacturers are using polyethylene glycol in wound care and other “natural” products sparked my interest in just how many of these products were on the market. You can change your mind and unsubscribe anytime. Cats, more than dogs, are sensitive to Propylene Glycol, especially if received in large doses over a period of time. Polyethylene glycol (PEG) or macrogol is a polyether compound. We recently showed how polyethylene glycol (PEG), a fusogen[1, 9] applied immediately on full transection of the spinal cord (so-called GEMINI protocol) can lead to motor recovery in mice, rats, and dogs. Depending on the way polyethylene glycol is manufactured, PEG can contain contaminants like ethylene oxide and 1,4-dioxane. Safety and palatability of polyethylene glycol 3350 as an oral laxative in cats. Polyethylene glycol 3350 should not be used in animals with gastrointestinal obstructions, rectal bleeding or a tear in the intestinal wall (bowel perforation), or toxic colitis. After we went through the usual dietary factors, we started to go over her environment and eventually her grooming products. The National Institute for Occupational Safety and Health (www.cdc.gov/niosh) notes: “Ethylene glycol is chemically broken down in the body into toxic compounds. Polyethylene glycol, otherwise known as PEG, is a mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid. PEG can accumulate in the body if it is able to penetrate the skin layer, affecting your dog’s skin and coat, nervous system, and beneficial bacteria. And do dog’s like sweet? Polyethylene glycol 3350. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. Polyethylene glycol (PEG) has been widely used as colonic cleansing solution for radiological and colonoscopy procedures for many years, as well as for the treatment of constipation in humans and dogs (Belsey et al. Polyethylene glycol, otherwise known as PEG, is a mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid. Recently, I was working with a dog who was suffering from severe itching and hair loss. polycyclic aromatic compounds, lead, cobalt, nickel, cadmium, and arsenic. Somehow, the chemical has worked its way into cosmetics, canine wellness products and medicine. Current Veterinary Therapy XV, Bonagura and Twedt. Polyethylene Glycol 3350, USP Powder for Oral Solution is a synthetic polyglycol having an average molecular weight of 3350. It is categorized by the FDA as a GRAS (generally recognized as safe) substance. Polyethylene glycol (PEG) 3350 is not. If you look at polyethylene glycol’s Material Safety Data Sheet (MSDS), under “Skin Contact” it reads: “Immediately flood affected skin with water while removing and isolating all contaminated clothing. Connect with Rita through her website canineherbalist.com. [3, 7, 8, 10] In this paper, we present the histological evaluation of the fusion process in dogs. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food.   Medication should never be administered without first consulting your veterinarian. It and its toxic by-products first affect the central nervous system, then the heart, and finally the kidneys. Rita combines nature with her love for dogs by offering consulting that focuses on dogs as individuals: mind, body and spirit.  Tam FM, Carr AP, Myers SL. If cats or dogs ingest large amounts of propylene glycol, poisoning can occur.. > Propylene glycol ingested at toxic doses can cause central nervous system depression and lactic acidosis, Brutlag says. Route of elimination. This allows a high absorption rate of any product containing polyethylene glycol. (www.cir-safety.org) CIR notes that PEG compounds “should not be used on damaged skin”. Experimentally, propylene glycol administration in dogs at 2 g/kg/day has caused no adverse effects. I encourage you to keep reading labels and looking up ingredients. Yes, I want to get emails from Dogs Naturally. PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Polyethylene glycol 3350 should not be used in animals with known hypersensitivity or allergy to the drug. In the case of our canine friends, my main concern comes with topical medication geared toward the healing of damaged skin and wounds. Take by mouth usually once daily, or as directed by your doctor or the directions on the product package.. mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid The oral LD 50 of PG in dogs is ~9 mL/kg. This product touted that it quickly healed wounds and could be used as a post-surgical application to speed the healing of incisions. Webster R, Didier E, Harris P, et al. Polyethylene glycol is a metabolically inert laxative that does not undergo intestinal enzymatic degradation or bacterial metabolism. The product was also being sold as an “all natural” solution for wound care. Polyethylene glycol 3350, commonly known as MiraLAX® as well by many other trade names (see below), is used as a laxative to treat constipation for dogs and cats. This warning is alarming for a topical product that directs you to rub it on damaged skin. Full recovery is possible and often rapid in people treated with bronchoalveolar lavage. Bethesda, MD, USA: American Society of Health-System Pharmacists; 2010. I know you would not give Myralax to your dog but you might unknowingly give PEG to them if you are not carefully reading labels. Propylene glycol is a synthetic liquid substance that absorbs water. Polyethylene glycol, more commonly known as PEG 400, is used as a plasticizer, surfactant, suppository base and ointment, solvent, and capsule and tablet lubricant in the pharmaceutical industry. J Feline Med Surg 2011. [src="https://a.omappapi.com/users/3d3cb4d2c858/images/c2386e4c35af1584128187-Pet-Food-Analyzer.png"], [src="https://a.omappapi.com/users/3d3cb4d2c858/images/5a91f54387991585949493-c2386e4c35af1584128187-Pet-Food-Analyzer.png"], German Chamomile: A Bit Of Herbal Sunshine For You And Your Dog, Raw Dog Food Primer: 6 Steps To Get Started, A Veterinarian’s Journey From Kibble To Raw. You might be more familiar with a product called Myralax, which is sold as a laxative. Don’t rely on the manufacturer. The International Agency for Research on Cancer (www.iarc.fr) has classified ethylene oxide as a known human carcinogen that can harm the nervous system and interfere with human development. Below 55°C it is a free flowing white powder freely soluble in water. Polyethylene glycol. The recommendations in this article are for the Polyethylene Glycol 3350 Powder for solution is available in either pre-measured 17 gram packets or bulk powder such as MiraLax®, Dulcolax Balance®, and various generic names. While generally safe and effective when prescribed by a veterinarian, Polyethylene glycol 3350 can cause side effects in some animals. How I knew that it was her post-surgical gel that was causing her itching and hair loss was that PEG causes problems with it comes in contact with broken or damaged skin. Experimentally, propylene glycol administration in dogs at 2 g/kg/day has caused no adverse effects.” Source: VeterinaryNews.DVM360.com. All Rights Reserved. Hopefully, as more information becomes available and more people complain about the use of the ingredient, they will leave polyethylene glycol to the paint and coatings manufacturers. When taken internally, PEG causes the colon to absorb water and produce a watery stool. Human formulations: There are several different trade name products for docusate. Propylene glycol is also used to make polyester compounds, and as a base for de-icing solutions. In: AHFS drug information 2010. Some pets will experience lethargy, nausea, vomiting, and/or increased thirst. Never exceed 3/4 teaspoon of Miralax for every 10 pounds of the dog’s body weight over a 24-hour period. Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. Polyethylene glycol 3350 normally causes loose or even watery stools. It is used in many products including medications such as ointments and pills to allow them to be more easily dissolved in water. Polyethylene glycol lavage solutions are used for colonic preparation in dogs and are considered relatively safe. The chemical formula is HO(C2H4O)nH in which n represents the average number of oxyethylene groups. 1,4-dioxane is a chemical that remains in the environment for long periods of time because it does not easily degrade. Do not use polyethylene glycol 3350 more than once per day. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. Such drugs include certain other laxatives and stool softeners. 2012). 5. 1,4-dioxane is listed as a possible human carcinogen. Of a diet containing 6 % –12 % PG can result in severe poisoning into cosmetics canine. Effective when prescribed by a veterinarian, propylene glycol is a colorless, odorless, syrupy..., 10 ] in this paper, we present the histological evaluation their! Working holistic vets who make this information possible we started to go over environment! The product package administered unless polyethylene glycol dogs the supervision and guidance of a diet containing 6 % –12 % PG result. 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Make this information possible types of macrogol exist according to Dr. Karen Becker, herbal. Is 1/8 to teaspoon BID, and pharmaceutical industries as an additive in pharmaceuticals, cosmetics food!